Distinct properties of glycine receptor β+/α- interfaces
نویسندگان
چکیده
Background: Heteromeric αβ glycine receptor β+/αinterfaces have never been unambiguously characterized. Results: This interface, compared with the α+/αinterface, is highly sensitive to agonist and experiences distinct conformational changes upon agonist binding. Conclusion: The β+/αinterface exhibits distinct properties. Significance: Our investigation directs the β+/αinterface-specific drug design and provides a general methodology for unambiguously characterizing heteromeric proteins interfaces.
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